MABC1608M

Anti-Mucin-16 (CA-125) Antibody, clone 5E11

• Szinonimák: MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 100
• antitest forma: purified antibody
• antitest terméktípus: primary antibodies
• klón: monoclonal
• faj reaktivitás: human
• technika/technikák: immunohistochemistry: suitable (paraffin); proximity ligation assay: suitable; western blot: suitable
• izotípus: IgG1κ
• NCBI elérési szám: NP_078966.2
• UniProt elérési szám: Q8WXI7
• kiszállítva: ambient
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... MUC16(94025)

Leírás

Általános leírás

Mucin-16 (UniProt: Q8WXI7; also known as MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125) is encoded by the MUC16 (also known as CA125) gene (Gene ID: 94025) in human. Mucin-16 is a heavily O-glycosylated protein that can be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus, which induces proteolytic cleavage and liberation of extracellular domain. I provides protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16 is composed of three domains: a Serine, Threonine-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane domain with a short cytoplasmic tail. Its expression is up-regulated in ovarian cancer cells and may serve as a marker for ovarian cancer. Mucin-16 is shown to binds to mesothelin (MSLN) and this binding mediates heterotypic cell adhesion, which may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium.

Minőség

Evaluated by Immunohistochemistry in human ovarian cancer and human uterine tissues.

Immunohistochemistry (Paraffin) Analysis: A 1:50-250 dilution of this antibody detected Mucin-16 in human ovarian cancer and human uterine tissues.

Cél megnevezése

1519.17 kDa calculated.

Fizikai forma

Format: Purified

Egyéb megjegyzések

Concentration: Please refer to lot specific datasheet.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable