ABN348

Anti-TTBK1 Antibody

from rabbit, purified by affinity chromatography

• Szinonimák: Tau tubulin kinase 1, brain derived tau kinase, BDTK, TTBK1
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• klón: polyclonal
• application: IHC; WB
• faj reaktivitás: human, mouse
• technika/technikák: immunohistochemistry: suitable; western blot: suitable

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• tisztítva: affinity chromatography
• faj reaktivitás: human, mouse
• technika/technikák: immunohistochemistry: suitable; western blot: suitable
• UniProt elérési szám: Q5TCY1
• kiszállítva: wet ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... TTBK1(84630)

Leírás

Általános leírás

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.

Egyediség

This antibody is predicted to not cross-react with TTBK2.

Immunogén

KLH-conjugated linear peptide corresponding to human TTBK1.

Alkalmazás

Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.

Minőség

Evaluated by Western Blot in Jurkat cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTBK1 in 15 µg of Jurkat cell lysate.

Cél megnevezése

~143 kDa observed

Fizikai forma

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

Tárolás és stabilitás

Stable for 1 year at 2-8°C from date of receipt.

Analízis megjegyzés

Control
Jurkat cell lysate

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable