ABE2622
Anti-SYCP2
serum, from rabbit
Szinonimák:
Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
polyclonal
application:
IF
WB
WB
faj reaktivitás:
mouse, human
technika/technikák:
immunofluorescence: suitable
western blot: suitable
western blot: suitable
citations:
1
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
antitest forma
serum
antitest terméktípus
primary antibodies
klón
polyclonal
faj reaktivitás
mouse, human
technika/technikák
immunofluorescence: suitable
western blot: suitable
NCBI elérési szám
UniProt elérési szám
kiszállítva
ambient
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... SYCP2(10388)
mouse ... Sycp2(320558)
Általános leírás
Synaptonemal complex protein 2 (UniProt: Q9CUU3; also known as SCP-2, SYCP2, Synaptonemal complex lateral element protein) is encoded by the Sycp2 (also known as Scp2) gene (Gene ID: 320558) in murine species.SYCP2 is present in testis and spermatocyte and is a major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase and plays a role in the assembly of synaptonemal complexes. It is required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. SYCP2 is considered to be a primary determinant of axial/lateral elements and can heterodimerize with SYCP3 and it is is required for the incorporation of SYCP3 into the synaptonemal complex. An evolutionarily conserved coiled coil domain in SYCP2 is required for binding to SYCP3. Defects in SYCP2 leads to sterility in male mice due to defective meiotic chromosome synapsis during spermatocyte development. Also, SYCP2 deficient mice show much reduced testes weight.
Egyediség
This polyclonal antibody detects Synaptonemal complex protein 2 in mouse testis and recognizes an epitope within amino acids 1255-1500 in the C-terminal region.
Immunogén
Epitope: C-terminus
His-tagged recombinant fragment corresponding to 246 amino acids from the C-terminal region of murine Synaptonemal complex protein 2.
Alkalmazás
Anti-SYCP2 , Cat. No. ABE2622, is a highly specific rabbit polyclonal antibody that targets Synaptonemal complex protein 2 and has been tested in Immunofluorescence and Western Blotting.
Immunofluorescence Analysis: A representative lot detected SYCP2 in spread nuclei of mouse spermatocytes. (Courtesy of Dr. P. Jeremy Wang at University of Pennsylvania).
Immunofluorescence Analysis: A representative lot detected SYCP2 in spread nuclei of oocytes and spermocytes (Yang, F., et. al. (2015). EMBO Mol Med. 7(9):1198-210).
Western Blotting Analysis: A representative lot detected SYCP2 in adult mouse testis tissue lysate (Yang, F., et. al. (2006). J Cell Biol. 173(4):497-507).
Immunofluorescence Analysis: A representative lot detected SYCP2 in spread nuclei of oocytes and spermocytes (Yang, F., et. al. (2015). EMBO Mol Med. 7(9):1198-210).
Western Blotting Analysis: A representative lot detected SYCP2 in adult mouse testis tissue lysate (Yang, F., et. al. (2006). J Cell Biol. 173(4):497-507).
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Minőség
Evaluated by Western Blotting in mouse testis tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected SYCP2 in 50 µg of mouse testis tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected SYCP2 in 50 µg of mouse testis tissue lysate.
Cél megnevezése
~200 kDa observed; 172.12 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Fizikai forma
Rabbit polyclonal anti-serum with 0.05% sodium azide.
Unpurified
Tárolás és stabilitás
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Egyéb megjegyzések
Concentration: Please refer to lot specific datasheet.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Samantha L P Schilit et al.
American journal of human genetics, 106(1), 41-57 (2019-12-24)
Unexplained infertility affects 2%-3% of reproductive-aged couples. One approach to identifying genes involved in infertility is to study subjects with this clinical phenotype and a de novo balanced chromosomal aberration (BCA). While BCAs may reduce fertility by production of unbalanced
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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