PTEN
phosphatase and tensin homolog
Szinonimák:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Faj:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), naked mole-rat Pten (101714930), domestic guinea pig Pten (100723659), sheep PTEN (101119351), cow PTEN (540786), domestic cat PTEN (101091813), dog PTEN (403832)
UniProtKB azonosító:
Gene ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- naked mole-rat(101714930) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
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Antibodies
Cikkszám
Leírás
Faj reaktivitás
Alkalmazás
Anti-PTEN antibody produced in rabbit, affinity isolated antibody,
Faj reaktivitás
human, mouse
Alkalmazás
ELISA
western blot
western blot
Anti-PTEN (Ab-370) antibody produced in rabbit, affinity isolated antibody,
Faj reaktivitás
human, mouse, rat
Alkalmazás
immunohistochemistry
western blot
western blot
Anti-phospho-PTEN (pSer380/pThr382/pThr383) antibody produced in rabbit, affinity isolated antibody,
Faj reaktivitás
human, mouse, rat
Alkalmazás
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PTEN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Faj reaktivitás
canine, human, mouse, rat
Alkalmazás
ELISA
western blot
western blot
Anti-Phospho-PTEN-S370 antibody produced in rabbit, ,
Faj reaktivitás
human, mouse, rat
Alkalmazás
western blot