SAB5700540

Anti-Phospho-PTEN-S370 antibody produced in rabbit

• Szinonimák: 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN, PTEN1, PTENbeta, TEP1
• UNSPSC kód: 12352203
• NACRES: NA.41
• klón: polyclonal
• application: WB
• faj reaktivitás: mouse, human, rat
• technika/technikák: western blot: 1:500-1:2000

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: 19; 47; 64
• faj reaktivitás: mouse, human, rat
• koncentráció: 0.81 mg/ml
• technika/technikák: western blot: 1:500-1:2000
• UniProt elérési szám: P60484
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: phosphorylation (pSer370)
• Géninformáció: human ... PTEN(5728)

Leírás

Általános leírás

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

Immunogén

A phospho specific peptide corresponding to residues surrounding S370 of human PTEN

Fizikai forma

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Tárolás és stabilitás

Store at -20℃. Avoid freeze / thaw cycles.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable