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Merck
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文件

SML1924

Sigma-Aldrich

T1AM

≥98% (HPLC)

别名:

3-碘胸腺嘧啶 盐酸盐, 4-[4-(2-氨基乙基)-2-?碘苯氧基]苯酚盐酸盐(1:1)

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About This Item

经验公式（希尔记法）:
C14H14INO2 · HCl
CAS号:
788824-64-6
分子量:
391.63
MDL號碼:
MFCD11973725
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

H2O: 10 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1.[H]Cl

InChI

1S/C14H14INO2.ClH/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12;/h1-6,9,17H,7-8,16H2;1H

InChI 密鑰

RVKVVMXTPQCCIX-UHFFFAOYSA-N

生化／生理作用

3-3-碘类甲腺质(T1AM)存在于脊椎动物组织和循环系统中。其生理作用与甲状腺激素相反。T1AM既是一种神经调节剂，也是一种激素样分子。
T1AM（3-3-碘类甲腺质）是一种源自甲状腺激素的内源性生物胺。 T1AM是痕量胺相关受体TAAR1 (TAR1, Ta1)的强效激动剂，而 TAAR1 是一种主要在大脑中发现的 GPCR。

象形圖

Exclamation markEnvironment
GHS07,GHS09

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Carolin Stephanie Hoefig et al.
Thyroid : official journal of the American Thyroid Association, 26(12), 1656-1673 (2016-09-22)
Thyronamines (3-T
Annunziatina Laurino et al.
European journal of pharmacology, 793, 35-42 (2016-11-07)
3-iodothyronamine (T1AM) is a trace amine suspected to derive from thyroid hormone metabolism. T1AM was described as a ligand of G-protein coupled monoaminergic receptors, including trace amine associated receptors, suggesting the amine may exert a modulatory role on the monoaminergic
Muhammad Zahid Khan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 439-449 (2016-10-25)
Human trace amines (TAs) are endogenous compounds, previously almost ignored in human pathology for many reasons (difficulty of their measurement in biological fluids, unknown receptors for elusive amines), are now considered to play a significant role in synaptic transmission within
Alexandra G Ianculescu et al.
Molecular bioSystems, 6(8), 1338-1344 (2010-07-14)
3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with distinct biological effects that are largely opposite those of thyroid hormone. Administration of T(1)AM to rodents results in rapid and profound reduction in body temperature, heart rate, and metabolism. The structural

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