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Merck

SMB00806

Sigma-Aldrich

7-Ketodeoxycholic acid

≥95% (HPLC)

别名:

3α,12α-Dihydroxy-7-oxo-5β-cholanoic acid, 7-Oxo-3α,12α-dihydroxy-5β-cholanoic acid

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About This Item

经验公式(希尔记法):
C24H38O5
CAS号:
分子量:
406.56
分類程式碼代碼:
41141802
NACRES:
NA.28

化驗

≥95% (HPLC)

形狀

powder

包裝

pkg of 1 g
pkg of 50 mg

顏色

off-white to beige

mp

193—198 °C

官能基

carboxylic acid
ketone

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C24H38O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-18,20,22,25,27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,20+,22+,23+,24-/m1/s1

InChI 密鑰

RHCPKKNRWFXMAT-RRWYKFPJSA-N

一般說明

7-Ketodeoxycholic acid, categorized as a oxo-5beta-cholanic acid, is a bile acid derivative and a metabolite resulting from the degradation of the primary bile acid, cholic acid, by intestinal bacteria. Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance. However, in specific liver conditions such as intrahepatic cholestasis characterized by reduced bile flow, the accumulation of bile acids at elevated concentrations can lead to severe toxic effects. This makes 7-Ketodeoxycholic acid a compound of interest for biochemical and metabolomics research.

應用

7-Ketodeoxycholic acid finds application in metabolomics, biochemical and microbiome research.

特點和優勢

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

其他說明

For additional information on our range of Biochemicals, please complete this form.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Takaaki Goto et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 846(1-2), 69-77 (2006-09-05)
We developed a highly sensitive and quantitative method to detect bile acid 3-sulfates in human urine employing liquid chromatography/electrospray ionization-tandem mass spectrometry. This method allows simultaneous analysis of bile acid 3-sulfates, including nonamidated, glycine-, and taurine-conjugated bile acids, cholic acid

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