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Merck
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文件

580549

Millipore

牛磺酸去氧胆酸，钠盐

Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

别名:

牛磺酸去氧胆酸，钠盐, 牛磺熊脱氧胆酸钠

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About This Item

经验公式（希尔记法）:
C26H44NO6S · Na
CAS号:
35807-85-3
分子量:
521.69
分類程式碼代碼:
12352106
NACRES:
NA.21

品質等級

100

化驗

≥97% (TLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white

溶解度

water: 100 mg/mL

運輸包裝

ambient

儲存溫度

15-25°C

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1

InChI 密鑰

BHTRKEVKTKCXOH-AYSJQVDDSA-N

相关类别

一般說明

用于溶解脂类和膜–结合蛋白质的洗涤剂。
用于溶解脂质和膜结合蛋白质的洗涤剂。对大鼠体内的疏水性胆盐具有冷冻保护作用。据报道也可抑制体外胃蛋白酶活性。

應用


  • Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.: This study highlights the efficacy of tauroursodeoxycholic acid, sodium salt in reducing endoplasmic reticulum stress, suggesting its utility in preventing vascular complications in diabetes (Gaikwad AB et al., 2022).

警告

毒性：标准处理（A）

其他說明

Ozcan, U., et al. 2006.Science313, 1137.
Miyake, H., et al. 1999.Dig.Dis.Sci.44, 197.
Eto, T. and Tompkins, R.K.1985.Am. J. Surg.150, 564.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Maddalena Parafati et al.
Disease models & mechanisms, 11(9) (2018-09-27)
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders prompted
Isabel Castro et al.
Rheumatology (Oxford, England), 59(4), 742-753 (2019-08-05)
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin
Huika Xia et al.
Investigative ophthalmology & visual science, 56(11), 6638-6645 (2015-10-16)
To investigate the effects of tauroursodeoxycholic acid (TUDCA) and alpha-lipoic-acid (ALA) on the visual response properties of cat retinal ganglion cells (RGCs) in wholemount retinas. Young adult cats were divided into three groups: control, ALA, and TUDCA. In vitro single-unit
Per Flodby et al.
American journal of respiratory cell and molecular biology, 55(1), 135-149 (2016-01-28)
Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, has been linked to endoplasmic reticulum (ER) stress. To investigate a causal role for ER stress in BPD pathogenesis, we generated conditional knockout (KO) mice (cGrp78(f/f)) with lung epithelial cell-specific KO
Yan Xie et al.
The Journal of biological chemistry, 282(45), 33043-33051 (2007-09-15)
Mammalian small intestinal lipid absorption requires the coordinated interactions of apolipoprotein B (apoB) and the microsomal triglyceride transfer protein (Mttp). The observation that apoB100 displays greater dependence on Mttp availability than does apoB48 prompted us to examine the phenotype of
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