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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
存貨情形
not available in Japan
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-6 μg/mL using human brain, neurons and glia
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−70°C
目標翻譯後修改
unmodified
基因資訊
human ... HTR2B(3357)
mouse ... Htr2b(15559)
rat ... Htr2b(29581)
一般說明
Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.
免疫原
synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.
生化／生理作用
The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.
標靶描述
The Serotonin 5-HT2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.
外觀
solution in phosphate buffered saline containing ≤0.1% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Multiple serotonin receptor subtypes: molecular cloning and functional expression.
Teitler M and Herrick-Davis K
Critical Reviews in Neurobiology, 8(3), 175-188 (1994)
Serotonin receptors and their function in sleep, anxiety disorders and depression.
Leonard B E, et al.
Psychotherapy and Psychosomatics, 65(2), 66-75 (1996)
Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505.
Kantor S, et al.
British Journal of Pharmacology, 142(8), 1332-1342 (2004)
Prenatal diagnosis of microdeletion 16p13.11 combination with partial monosomy of 2q37.1-qter and partial trisomy of 7p15.3-pter in a fetus with bilateral ventriculomegaly, agenesis of corpus callosum, and polydactyly.
Sung P L, et al.
Taiwanese Journal of Obstetrics & Gynecology, 51(2), 260-265 (2012)
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