A7257

(−)-去甲肾上腺素

≥98% (TLC), crystalline, adrenergic neurotransmitter

• 别名: (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol
• 经验公式（希尔记法）: C₈H₁₁NO₃
• CAS号: 51-41-2
• 分子量: 169.18
• Beilstein: 2804840
• EC號碼: 200-096-6
• MDL號碼: MFCD00025592
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24891196
• NACRES: NA.77

属性

• product name: (−)-去甲肾上腺素, ≥98%, crystalline
• 化驗: ≥98%
• 形狀: crystalline
• 顏色: off-white to tan
• 儲存溫度: −20°C
• SMILES 字串: NC[C@H](O)c1ccc(O)c(O)c1
• InChI: 1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
• InChI 密鑰: SFLSHLFXELFNJZ-QMMMGPOBSA-N
• 基因資訊: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155) ; rat ... Adra1a(29412) , Adra1d(29413) , Adra2a(25083) , Adrb1(24925) , Adrb2(24176) , Drd1a(24316) , Drd2(24318)

说明

一般說明

Norepinephrine is a neurotransmitter found in both the peripheral and central nervous systems. It triggers effects associated with the ′fight or flight′ response and is mediated by the family of adrenergic receptors. Structurally, it is a catecholamine due to the presence of the catechol moiety (consisting of two hydroxyl groups on a benzene ring) and an amine (NH2) group. Norepinephrine exhibits pharmacologic effects on α1 and β1 adrenoceptors. It does not elevate heart rate. The primary advantage of norepinephrine is to improve organ perfusion by increasing vascular tone. Compared to dopamine, norepinephrine is more effective at achieving targeted endpoints, less metabolically active than epinephrine, and reduces serum lactate levels. Moreover, it notably enhances renal perfusion and splanchnic blood flow in sepsis, especially when used alongside dobutamine. Norepinephrine is used in the treatment of hypotension, depression, schizophrenia, and attention deficit/hyperactivity disorders.

應用

(−)-Norepinephrine has been used:

• as anαand β-AR agonist to stimulate mouse organoids to study the pathways that are activated upon intestinal epithelial adrenergic receptor (AR) stimulation,
• to measure the monoamine levels in various limbic regions of mouse brains by high-performance liquid chromatography (HPLC) coupled with an electrochemical equipped with an auto-sampler,
• as a dispersal agent in biofilm dispersion assay to study its effects on the dispersal of Mannheimia haemolytica biofilms

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330
• 防範說明: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危險分類: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• 儲存類別代碼: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges