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Merck
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文件

I3536

Sigma-Aldrich

人胰岛素

recombinant, expressed in yeast, γ-irradiated, suitable for cell culture

别名:

胰岛素 人

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About This Item

经验公式（希尔记法）:
C257H383N65O77S6
CAS号:
11061-68-0
分子量:
5807.57
MDL號碼:
MFCD00131380
分類程式碼代碼:
12352209
NACRES:
NA.77

重組細胞

expressed in yeast

品質等級

200

無菌

γ-irradiated

形狀

lyophilized powder

效力

≥25 USP units per mg

技術

cell culture | mammalian: suitable

溶解度

0.01 M HCl: 20 mg/mL, clear, colorless to faintly yellow

UniProt登錄號

P01308

運輸包裝

ambient

儲存溫度

−20°C

InChI 密鑰

PBGKTOXHQIOBKM-FHFVDXKLSA-N

基因資訊

human ... INS(3630)

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相关类别

一般說明

INS基因会编码胰岛素原前体，其可被酶促转化为胰岛素。胰岛素是在产胰岛素胰岛β细胞中生成的。前胰岛素原是在内质网中被转化为胰岛素原的，并随后通过蛋白水解在新形成的胰岛素分泌颗粒中形成胰岛素。胰岛素的产生受到INS启动子近端区域内∼400 bp之内特定DNA元件的严格调控。

應用

人胰岛素已用于以下应用：
  • 成脂分化测定（在制备培养基补充剂中）
  • 孵育用于评估胰岛素作用的细胞
  • 质谱（用于外部校准）

生化／生理作用

由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。
胰岛素负责两种类型的作用- 兴奋性和抑制性。在其兴奋作用中，它可增加葡萄糖和脂质合成的摄取，而在其抑制作用中它可抑制糖原分解、糖异生、脂解、蛋白水解和生酮作用。胰岛素分泌异常会导致各种疾病，如糖尿病、高血糖症或低血糖症。I型糖尿病是胰腺β细胞自身免疫破坏的结果，可导致胰岛素耗竭。突变体INS基因诱导的青年糖尿病（MIDY）综合征是一种由错义突变引起的常染色体显性遗传疾病，可导致异常的胰岛素原折叠。葡萄糖耐量降低（IGT）或非胰岛素依赖型糖尿病（NIDDM）是由对胰岛素刺激的葡萄糖摄取的抵抗而引起的。

其他說明

InChI：1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°C）

Not applicable

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