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Merck

D2773

Sigma-Aldrich

地蒽酚

≥90% (HPLC)

别名:

1,8,9-蒽三酚, 1,8-二羟基蒽-9(10H)-酮, 二羟蒽酚, 蒽林

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About This Item

经验公式(希尔记法):
C14H10O3
CAS号:
分子量:
226.23
Beilstein:
2054360
EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25

化驗

≥90% (HPLC)

形狀

solid

mp

178-181 °C (lit.)

溶解度

chloroform: 20 mg/mL, clear to very slightly hazy, yellow

SMILES 字串

Oc1cccc2Cc3cccc(O)c3C(=O)c12

InChI

1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2

InChI 密鑰

NUZWLKWWNNJHPT-UHFFFAOYSA-N

基因資訊

mouse ... Alox12(11684)

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一般說明

地蒽酚(1,8-二羟基-9-蒽酮)也称为 anthralin。它是一种重要的外用抗牛皮癣药物。地蒽酚是一种蒽衍生物,是一种自由基可产生线粒体毒素,线粒体毒素可诱导角质细胞发生细胞凋亡。

應用

地蒽酚,一种潜在的抗牛皮癣药物,可用于研究其安全性、功效、代谢和药理学特征。地蒽酚可用于研究其物理化学性质,作为一种参考化合物并开发有效的药物运输载体。地蒽酚可用作傅立叶变换离子回旋共振质谱仪上的基质辅助激光解吸/电离成像的基质。

其他說明

为了全面了解我们针对客户研究提供的各种多糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Wing Man Lau et al.
Pharmaceutics, 5(2), 232-245 (2013-12-05)
Psoriasis is a common, chronic and relapsing inflammatory skin disease. It affects approximately 2% of the western population and has no cure. Combination therapy for psoriasis often proves more efficacious and better tolerated than monotherapy with a single drug. Combination
Alison McGill et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(8), 1012-1014 (2005-04-02)
Anthralin is a potent topical drug, inducing clearance of psoriatic plaques. Anthralin disrupts mitochondrial function and structure, but its mechanism of action remains undefined. This study aimed to determine whether anthralin induced keratinocyte apoptosis as well as to investigate molecular
Brian L Watson et al.
Physical chemistry chemical physics : PCCP, 17(24), 15788-15796 (2015-05-29)
A new sensitizer motif for dye sensitized solar cells (DSSC) has been developed. A heteroaromatic moiety containing a pyrazine ring links two porphyrin chromophores to the metal oxide surface via two carboxylic acid attachment groups. A test DSSC sensitized with
C Salet et al.
Archives of dermatological research, 283(3), 186-190 (1991-01-01)
Isolated mitochondria were used to determine what causes anthralin inhibition of oxidative phosphorylation. In good agreement with other results, the rate of oxygen consumption was not modified by anthralin when mitochondria were first uncoupled with FCCP, suggesting that only the
G C Hsieh et al.
Toxicology and applied pharmacology, 107(1), 16-26 (1991-01-01)
Primary cultured rat epidermal keratinocytes were used as an experimental model to detect oxidant-mediated adverse effects of dithranol (anthralin), a widely used antipsoriasis drug with tumor-promoting and skin-irritating properties. Keratinocytes were isolated and prepared from the skin of neonatal rats

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