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一般說明
Sodium trifluoroacetate is a trifluoromethylating agent for compounds like aromatic halides, aldehydes and ketones.
應用
Sodium trifluoroacetate can be used:
- As a trifluoromethylating agent in nucleophilic trifluoromethylation of aldehydes using copper(I) halide catalyst.
- As a difluorocarbene precursor in gem-difluorocyclopropanation of different alkenes using azobisisobutyronitrile (AIBN) as a catalyst.
- In the synthesis of trifluoromethylthio-substituted aromatic compounds via copper-mediated oxidative trifluoromethylthiolation of aryl boronic acids in the presence of elemental sulfur.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Copper-mediated oxidative trifluoromethylthiolation of aryl boronic acids with CF3CO2Na and elemental sulfur
Tetrahedron, 69(48), 10262-10266 (2013)
Journal of the American Society for Mass Spectrometry, 30(3), 489-500 (2018-12-16)
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Sodium trifluoroacetate: an efficient difluorocarbene precursor for alkenes
Chemistry Letters (Jpn), 34(10), 1440-1441 (2005)
Dalton transactions (Cambridge, England : 2003), 49(27), 9444-9453 (2020-07-01)
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Sodium trifluoroacetate: an efficient precursor for the trifluoromethylation of aldehydes
Tetrahedron Letters, 46(18), 3161-3164 (2005)
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