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等級
pharmaceutical primary standard
API 家族
cisplatin
製造商／商標名
EDQM
mp
270 °C (lit.)
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
N.N.Cl[Pt]Cl
InChI
1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI 密鑰
LXZZYRPGZAFOLE-UHFFFAOYSA-L
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一般說明
應用
本欧洲药典参考标准仅用于欧洲药典中明确规定的用途。不保证适用于任何其他用途，用户请自行负责。本标准品不适用于人类或动物使用。
根据欧洲药典，用于配制下列给定溶液：
根据欧洲药典，用于配制下列给定溶液：
- 鉴定参考溶液，根据各论 0559，采用红外吸收光谱法和薄层色谱法检测相关物质，使用采用液相色谱法（通则 2.2.29）检测顺铂
- 参考溶液 (b)，根据各论 1081，使用液相色谱法（通则 2.2.29）检测异麦芽酮糖醇中的相关物质
生化／生理作用
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
包裝
本品按照现行药典要求提供。有关当前单位数量，请见EDQM 参考目录。
其他說明
相应销售限制条件可能适用。
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Cisplatin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 2231-2232 (2009)
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European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
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Yi-Long Wu et al.
The Lancet. Oncology, 14(8), 777-786 (2013-06-21)
The results of FASTACT, a randomised, placebo-controlled, phase 2 study, showed that intercalated chemotherapy and erlotinib significantly prolonged progression-free survival (PFS) in patients with advanced non-small-cell lung cancer. We undertook FASTACT-2, a phase 3 study in a similar patient population.
Michael F Milosevic et al.
International journal of cancer, 135(7), 1692-1699 (2013-08-02)
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