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Merck
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44583

Sigma-Aldrich

阿霉素 盐酸盐

suitable for fluorescence, 98.0-102.0% (HPLC)

别名:

DOX, 多柔比星® 盐酸盐, 羟基柔红霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C27H29NO11 · HCl
CAS号:
25316-40-9
分子量:
579.98
Beilstein:
4229251
EC號碼:
246-818-3
MDL號碼:
MFCD00077757
分類程式碼代碼:
51281818
PubChem物質ID:
57650234
NACRES:
NA.76

生物源

synthetic

品質等級

200

化驗

98.0-102.0% (HPLC)

形狀

solid

顏色

orange to dark red

mp

216 °C (dec.) (lit.)

溶解度

H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble

螢光

λem 580-590 nm

適合性

suitable for fluorescence

抗生素活性譜

neoplastics

作用方式

DNA synthesis | interferes
enzyme | inhibits

儲存溫度

2-8°C

SMILES 字串

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI 密鑰

MWWSFMDVAYGXBV-RUELKSSGSA-N

基因資訊

human ... TOP2A(7153)

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相关类别

一般說明

化学结构：四环素

應用

阿霉素用于诱导细胞凋亡，并在 SK-N-MC 细胞中诱导心脏毒性。它用于抑制大分子的生物合成。

生化／生理作用

阿霉素是一种插入 DNA 并抑制大分子生物合成的抗肿瘤抗生素。由于拓扑异构酶 II 的抑制，DNA 复制被牵引。 它是逆转录酶和 RNA 聚合酶的抑制剂，是一种免疫抑制剂。

包裝

无底玻璃瓶。内含物装在锥底内插管中。

其他說明

保存于密闭容器内，置于干燥通风处。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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柔红霉素 盐酸盐 European Pharmacopoeia (EP) Reference Standard

D0125000

柔红霉素 盐酸盐

紫杉醇 from semisynthetic, ≥98%

Sigma-Aldrich

T7191

紫杉醇

R L Momparler et al.
Cancer research, 36(8), 2891-2895 (1976-08-01)
The effect of adriamycin on DNA, RNA, and protein synthesis was investigated in cell-free systems and intact cells. In studies with purified mammalian cell enzymes, adriamycin produced a greater inhibition of DNA-dependent DNA polymerase than of RNA polymerase. The extent
Shujun Zhang et al.
Journal of natural products, 69(10), 1425-1428 (2006-10-28)
Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization
Michael A Skinner et al.
Anticancer research, 28(4B), 2019-2025 (2008-08-30)
Medullary thyroid cancer (MTC) is generally resistant to chemotherapy and the frequent constitutive activation of RET (rearranged during transfection gene) in these tumors might inhibit drug-induced apoptosis. Each RET isoform was separately expressed in SK-N-MC cells (neural crest-derived tumor) and
Shuai Li et al.
Journal of biomedical nanotechnology, 10(8), 1480-1489 (2014-07-16)
Amphiphilic copolymers have been paid much attention for controlled drug release for many years due to their obvious advantages. In this study, an acid-triggered drug carrier system capable of rapid intracellular drug release is investigated for potential tumor therapy. The
Lisa Fujimura et al.
Cardiovascular research, 64(2), 315-321 (2004-10-16)
The Ndl gene, which encodes a novel kelch family protein, is expressed ubiquitously in mouse tissues. In vitro studies suggest that Ndl protein, which binds to actin filaments, functions as a cytoskeletal stabilizer. In order to elucidate a physiological function
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