492028

NRG1-β1/HRG1-β1 ECD, Human, Recombinant

• 分類程式碼代碼: 12352203
• NACRES: NA.77

属性

• 化驗: ≥90% (SDS-PAGE)
• 品質等級: 100
• 形狀: lyophilized
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 雜質: ≤1.0 EU/μg protein Endotoxin
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Recombinant, human neuregulin 1-β1/heregulin 1-β1 extracellular domain (NRG1-beta1/HRG1-beta1 ECD) consisting of amino acids 2-246 and expressed in E. coli. All NRG1 isoforms contain an EGF-like domain (β-splice variant) that is used to directly bind to the ErbB3 or ErbB4 receptor tyrosine kinases.

生化／生理作用

ED₅₀ = 2.5-12.5 ng/ml as measured in a serum-free proliferation assay using MCF7 human breast adenocarcinoma cells.

警告

Toxicity: Standard Handling (A)

外觀

Lyophilized from 0.2 µm filtered acetonitrile, TFA, BSA.

重構

Following reconstitution refrigerate (4°C) for short term-storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Reconstitute 50 100 µg/ml with sterile PBS containing ≥1% human or bovine serum albumin.

其他說明

Buonanno, A., and G.D Fischbach 2001. Curr. Opin. Neurobiol.11, 287.
Adlkofer, K. and C. Lai 2000. Glia29, 104.
Garratt, A.N. et al., 2000. BioEssays22, 987.
Karey, K.P., et al. 1988. Cancer Res.48, 4083.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3