推荐产品
product name
TGF-β RI激酶抑制剂II, TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC₅₀ = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
品質等級
化驗
≥95% (HPLC)
形狀
solid
效力
23 nM IC50
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
yellow
溶解度
DMSO: 5 mg/mL
methanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI 密鑰
LBPKYPYHDKKRFS-UHFFFAOYSA-N
一般說明
TGF-βⅠ型受体的细胞渗透性、有效性、选择性、可逆性和ATP竞争性抑制剂（ALK5；ALK5结合、ALK5自动磷酸化和HepG2细胞中TGF-β细胞分析的IC50分别为23 nM、4 nM和18 nM）。对包括p38 MAPK（IC50 >16 µM）在内的9种密切相关的激酶组的影响最小。
一种细胞渗透性萘啶基吡唑化合物，可作为TGF-βⅠ型受体的有效、选择性、可逆和ATP竞争性抑制剂（ALK5；ALK5结合、ALK5自动磷酸化和HepG2细胞中TGF-β细胞分析的IC50分别为23 nM、4 nM和18 nM）。对9种密切相关的激酶的影响最小，包括IC50 >16 µM的p38 MAPK。也可作为50 mM的DMSO溶液（目录号508158）提供。
生化／生理作用
主靶
ALKS结合
ALKS结合
产物与ATP竞争。
次级靶标
ALK 5自身磷酸化(IC₅₀= 4 nM)
ALK 5自身磷酸化(IC₅₀= 4 nM)
细胞可渗透性：是
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
其他說明
Gellibert, F., et al. 2004.J. Med. Chem.47, 4494.
Ichida, J. K., et al. 2009.Cell Stem Cell 5, 491.
Ichida, J. K., et al. 2009.Cell Stem Cell 5, 491.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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