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Merck
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文件

475989

Sigma-Aldrich

噻唑蓝四唑蓝

Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan.

别名:

噻唑蓝四唑蓝, 3-（4，5-二甲基-2-噻唑）-2,5-二苯基-2H-溴化四唑噻唑蓝

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About This Item

经验公式（希尔记法）:
C18H16BrN5S
CAS号:
298-93-1
分子量:
414.32
MDL號碼:
MFCD00011964
分類程式碼代碼:
12171500
NACRES:
NA.25

品質等級

100

化驗

≥98% (silver nitrate titration)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

雜質

≤0.5% Sulfated ash

顏色

yellow

溶解度

PBS: 2 mg/mL

正離子痕跡

heavy metals: ≤0.001%

運輸包裝

ambient

儲存溫度

15-25°C

InChI

1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1

InChI 密鑰

AZKSAVLVSZKNRD-UHFFFAOYSA-M

相关类别

一般說明

一种膜渗透性黄色染料，在活细胞中被线粒体还原酶还原形成深蓝色产物MTT-甲臜。MTT-甲臜在540或570 nm处的分光光度测量可定量细胞活力。用作细胞毒性（如用于筛选癌症药物）和凋亡的直接指标。一种用于研究NADP依赖性脱氢酶类的电子受体。

生化／生理作用

主要靶标
用作细胞毒性和凋亡的直接指标。
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有

警告

毒性：有害 & 致癌/致畸性（E）

重構

复溶后，分装并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多1个月。

其他說明

Liu, Y., et al. 1997.J. Neurochem.69, 581.
Abdallah, M.A. 1980.Eur. J. Biochem.112, 331.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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