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Merck
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文件

548081

Sigma-Aldrich

2,4-二氟苯磺酰氯

97%

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About This Item

线性分子式:
F2C6H3SO2Cl
CAS号:
13918-92-8
分子量:
212.60
MDL號碼:
MFCD00042481
分類程式碼代碼:
12352100
PubChem物質ID:
24879012
NACRES:
NA.22

化驗

97%

折射率

n20/D 1.518 (lit.)

bp

236-237 °C (lit.)

密度

1.581 g/mL at 25 °C (lit.)

SMILES 字串

Fc1ccc(c(F)c1)S(Cl)(=O)=O

InChI

1S/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H

InChI 密鑰

FJSAJUXIHJIAMD-UHFFFAOYSA-N

一般說明

2,4-Difluorobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.

應用

2,4-Difluorobenzenesulfonyl chloride may be used in the preparation of 2,4-difluoro-N,N-dimethylbenzenesulfonamide, a precursor for poly(aryl ether sulfonamide)s.
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
  • 2,4-difluoro-N-methyl-N-(quinolin-8-yl)benzenesulfonamide
  • N-ethyl-2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
  • 2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

230.0 °F - closed cup

閃點（°C）

110 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

分析证书(COA)

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访问文档库

Fudi Zhong et al.
Organic & biomolecular chemistry, 13(6), 1792-1799 (2014-12-17)
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened a commercial library and identified the
Sulfonamide as an Activating Group for the Synthesis of Poly (aryl ether sulfonamide) s by Nucleophilic Aromatic Substitution.
Rebeck NT and Knauss DM.
Macromolecules, 44(17), 6717-6723 (2011)

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