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H4036

SAFC

L-histidine monohydrochloride monohydrate

Fabrication pharma

Synonyme(s) :

Acide L-α-amino-β-(4-imidazolyl)propionique monohydrochloride

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About This Item

Formule empirique (notation de Hill):
C6H9N3O2 · HCl · H2O
Numéro CAS:
5934-29-2
Poids moléculaire :
209.63
Numéro Beilstein :
4168261
Numéro MDL:
MFCD00151027
Code UNSPSC :
12352209
eCl@ss :
32160406
Nomenclature NACRES :
NA.26

Source biologique

non-animal source

Niveau de qualité

400

Pureté

≥98.5%

Forme

powder

Fabricant/nom de marque

Ajinomoto

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, heavy metals, residual solvents, tested

Pf

254 °C (dec.) (lit.)

Solubilité

H2O: 50 mg/mL

Application(s)

pharmaceutical (small molecule)

Activité étrangère

cytotoxicity, tested

Chaîne SMILES 

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

Clé InChI

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Catégories apparentées

Description générale

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Histidine, an essential amino acid. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Histidine monohydrochloride monohydrate is a modified version of L-Histidine with improved solubility.

Informations légales

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Bakul Bhatnagar et al.
The journal of physical chemistry. B, 123(27), 5690-5699 (2019-07-02)
Protein/ice interactions are investigated by a novel method based on measuring the characteristic features of X-ray diffraction (XRD) patterns of hexagonal ice (Ih). Aqueous solutions of four proteins and other solutes are studied using high-resolution synchrotron XRD. Two pharmaceutical proteins
Martin Maldonado et al.
Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro
Verena Saller et al.
Journal of pharmaceutical sciences, 104(4), 1440-1450 (2015-01-22)
In a typical manufacturing setup for biopharmaceutical drug products, the fill and dosing pump is placed after the final sterile filtration unit in order to ensure adequate dispensing accuracy and avoid backpressure peaks. Given the sensitivity of protein molecules, peristaltic
Nam Ah Kim et al.
Drug development and industrial pharmacy, 41(2), 300-306 (2014-02-08)
Correlation of thermodynamic and secondary structural stability of proteins at various buffer pHs was investigated using differential scanning calorimetry (DSC), dynamic light scattering (DLS) and attenuated total reflection Fourier-transform infrared spectroscopy (ATR FT-IR). Recombinant human epithelial growth factor (rhEGF) was
Aldo Roda et al.
The Analyst, 139(24), 6494-6501 (2014-10-25)
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