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H5659

Sigma-Aldrich

L-histidine monohydrochloride monohydrate

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonyme(s) :

Acide L-α-amino-β-(4-imidazolyl)propionique monohydrochloride

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About This Item

Formule empirique (notation de Hill):
C6H9N3O2 · HCl · H2O
Numéro CAS:
5934-29-2
Poids moléculaire :
209.63
Numéro Beilstein :
4168261
Numéro MDL:
MFCD00151027
Code UNSPSC :
12352209
eCl@ss :
32160406
ID de substance PubChem :
24895703
Nomenclature NACRES :
NA.26

product name

L-histidine monohydrochloride monohydrate, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

Source biologique

non-animal source

Agence

meets EP testing specifications

Gamme de produits

BioXtra

Pureté

98.5-101.0%

Forme

crystalline powder

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Couleur

white

Pf

254 °C (dec.) (lit.)

Solubilité

H2O: 100 mg/mL

Chaîne SMILES 

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

Clé InChI

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Catégories apparentées

Application

L-Histidine monohydrochloride monohydrate has been used in bee cell culture medium.
L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

Actions biochimiques/physiologiques

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Yoshihiro Kaneko et al.
Journal of bioscience and bioengineering, 109(3), 274-280 (2010-02-18)
Pharmaceutical manufacturing plants can be operated continuously for several months. It is therefore important to use cells with long-term stability for the production of active ingredients. We investigated the reliability and long-term stability of an antibody-producing cell line. A recombinant
Jean-Christophe Drugmand et al.
Biotechnology advances, 30(5), 1140-1157 (2011-10-11)
Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of baculovirus expression vector systems (BEVS), constitutes a powerful platform, IC-BEVS, for the abundant and
D J Williams et al.
IEE proceedings. Nanobiotechnology, 152(6), 207-210 (2006-01-31)
Tissue engineering and regenerative medicine are interdisciplinary fields that apply principles of engineering and life sciences to develop biological substitutes, typically composed of biological and synthetic components, that restore, maintain or improve tissue function. Many tissue engineering technologies are still
Medium for development of bee cell cultures (Apis mellifera: Hymenoptera: Apidae).
Hunter WB
In Vitro Cellular & Developmental Biology. Animal, 46(2), 83-86 (2010)
Carlota Diaz Sanchez-Bustamante et al.
Biotechnology and bioengineering, 93(1), 169-180 (2005-10-29)
A precise understanding of processes managing heterologous protein production in vitro and in vivo is essential for the manufacture of sophisticated biopharmaceuticals as well as for future gene therapy and tissue engineering initiatives. Capitalizing on the gravity-enforced self-assembly of monodispersed
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