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938785

Sigma-Aldrich

Sodium tert-butoxide ChemBeads

new

Synonyme(s) :

NaOtBu, Sodium 2-methylpropan-2-olate, Sodium t-butoxide, Sodium tert-butanolate, Sodium tert-butylate

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About This Item

Numéro CAS:
865-48-5
Numéro MDL:
MFCD00040575
Code UNSPSC :
12352100

Forme

solid ()

Niveau de qualité

100

Composition

loading of base, 14-16 wt. %

Chaîne SMILES 

[Na+].CC(C)(C)[O-]

InChI

1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1

Clé InChI

MFRIHAYPQRLWNB-UHFFFAOYSA-N

Application

Sodium tert-butoxide may be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine with diethyl p-toluenesulfonyloxymethanephosphonate to form 9-[2-(diethylphosphonomethoxy)ethyl]adenine (diethyl-PMEA), which is a key intermediate to prepare adefovir dipivoxil.
It can also be used:
- To facilitate the coupling of aryl halides with benzene derivatives in the presence of 10-phenanthroline derivative.
- To activate first-row transition-metal pre-catalysts.
- As a base for the amination of aryl chlorides in the presence of a novel palladacyclic precatalyst.
For general uses, product is also available in powdered form (359270)

Caractéristiques et avantages

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

359270

Sodium tert-butoxide, 97%

938769

Potassium carbonate ChemBeads

939005

Cesium Fluoride ChemBeads, NSC 84270

939056

Sodium phosphate ChemBeads

939013

Copper(I) iodide ChemBeads

938998

Sodium hydroxide ChemBeads

939048

Lithium bis(trimethylsilyl)amide ChemBeads

939021

Sodium carbonate ChemBeads

939064

Lithium hydroxide ChemBeads

Pictogrammes

FlameCorrosion
GHS02,GHS05

Mention d'avertissement

Danger

Mentions de danger

H228,H251,H314

Classification des risques

Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1B

Risques supp

EUH014

Code de la classe de stockage

4.2 - Pyrophoric and self-heating hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number
MKCW2494

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Consulter la Bibliothèque de documents

Noah P Tu et al.
Angewandte Chemie (International ed. in English), 58(24), 7987-7991 (2019-03-21)
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents
Ana L Aguirre et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(51), 12981-12986 (2021-07-08)
High-throughput experimentation (HTE) methods are central to modern medicinal chemistry. While many HTE approaches to C-N and Csp2 -Csp2 bonds are available, options for Csp2 -Csp3 bonds are limited. We report here how the adaptation of nickel-catalyzed cross-electrophile coupling of

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