U-99194 maleate has been used as a dopaminergic antagonist to study its effects on immobility episodes[1] and yawning frequency[2] in rats.
Acciones bioquímicas o fisiológicas
U-99194 is a putative D3 antagonist with a 30-fold preference for the dopamine D3 vs. D2 receptor.
Características y beneficios
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota de preparación
U-99194 maleate salt is soluble in water at a concentration >5 mg/ml.
Journal of neural transmission. General section, 102(3), 209-220 (1995-01-01)
Compounds showing an in vitro binding preference for the dopamine D3 vs. D2 receptors were tested for effects on locomotor activity after local application in the nucleus accumbens (N Acc) and the ventral tegmental area (VTA) of the rat brain.
The taiep rat is a myelin mutant whose immobility episodes (IEs) can be caused by gripping them by the tail. Electroencephalographic recordings during IEs show a rapid-eye movement sleep-like pattern, similar to narcolepsy-cataplexy in canines. Systemic administration of alpha(2)-adrenoceptor agonists
Pharmacology, biochemistry, and behavior, 102(1), 118-123 (2012-04-14)
Systemic administration of D2-like dopaminergic-receptor agonists increases yawning behavior. However, only a few studies have been done in animals with pathological conditions. The taiep rat is a myelin mutant with an initial hypomyelination followed by progressive demyelination, being the brainstem
Journal of neural transmission. General section, 94(1), 11-19 (1993-01-01)
We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the
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