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H9523

Sigma-Aldrich

Serotonin hydrochloride

≥98%, powder, neurotransmitter

Sinónimos:

3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C10H12N2O · HCl
Número de CAS:
153-98-0
Peso molecular:
212.68
Beilstein:
3570963
Número MDL:
MFCD00012686
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278124
NACRES:
NA.77

product name

Serotonin hydrochloride, powder

Análisis

≥98%

formulario

powder

color

white to off-white

mp

149-154 °C (lit.)

solubilidad

H2O: 17 mg/mL
0.1 M HCl: 22 mg/mL
ethanol: 5.3 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cl[H].NCCc1c[nH]c2ccc(O)cc12

InChI

1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H

Clave InChI

MDIGAZPGKJFIAH-UHFFFAOYSA-N

Información sobre el gen

human ... HTR3A(3359)

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Descripción general

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

Aplicación

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

Acciones bioquímicas o fisiológicas

Neurotransmitter.

Características y beneficios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Solutions should be freshly prepared.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Frases de peligro

H301,H361

Clasificaciones de peligro

Acute Tox. 3 Oral - Repr. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sara Redenšek Trampuž et al.
Scientific reports, 14(1), 1396-1396 (2024-01-17)
Non-alcoholic steatohepatitis (NASH) is a major health problem leading to liver fibrosis and hepatocellular carcinoma, among other diseases, and for which there is still no approved drug treatment. Previous studies in animal models and in LX-2 cells have indicated a
Soaleha Shams et al.
Behavioral neuroscience, 131(6), 492-504 (2017-12-01)
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although isolation effects have been reported in social mammals and various fish species, systematic studies with isolated zebrafish are rare. Here, the
Vinay Kumar Sharma et al.
Research square (2023-02-16)
5-Hydroxy tryptamine receptor 1E (5-HTR1E) is reported to activate cAMP and ERK pathways via its ligands and binding partners, but the detailed mechanism underlying the serotonin induced 5-HTR1E signaling is still not known. In the present study, we determined the
Serotonin Receptors
Nichols David E and Nichols Charles D.
Chemical Reviews (2008)
Rhian Stavely et al.
Inflammatory bowel diseases, 24(5), 1021-1034 (2018-04-19)
Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious
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Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

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