D054

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), solid

• Sinónimos: R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₁₈ClNO · HCl
• Número de CAS: 125941-87-9
• Peso molecular: 324.24
• Número MDL: MFCD00069249
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277910
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• actividad óptica: [α]/D +32.1°, c = 1 in DMF(lit.)
• condiciones de almacenamiento: desiccated; protect from light
• color: white
• solubilidad: H₂O: >5 mg/mL
• cadena SMILES: Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
• InChI: 1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
• Clave InChI: OYCAEWMSOPMASE-XFULWGLBSA-N
• Información sobre el gen: human ... DRD1(1812)

Descripción

Aplicación

R(+)-SCH-23390 hydrochloride has been used:

• for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
• as a D1 receptor-selective antagonist for intracranial drug infusions
• as an antagonist of D1 receptor to study its effect on learning ability in fish

Acciones bioquímicas o fisiológicas

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Características y beneficios

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información legal

Sold with the permission of Schering-Plough.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)