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917664

Sigma-Aldrich

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride

≥95%

Sinónimos:

Semi-flexible linker for PROTAC® development

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About This Item

Fórmula empírica (notación de Hill):
C13H20ClNO
Peso molecular:
241.76
Código UNSPSC:
12352116

Nivel de calidad

100

Análisis

≥95%

formulario

powder and chunks

idoneidad de la reacción

reagent type: linker

grupo funcional

hydroxyl

temp. de almacenamiento

2-8°C

cadena SMILES

OCCC1=C(C2CCNCC2)C=CC=C1.Cl

Aplicación

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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