917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

≥95%

• Sinónimos: Semi-flexible linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₃H₂₂Cl₂N₂
• Peso molecular: 277.23
• UNSPSC Code: 12352116
• Assay: ≥95%
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: NCCC1=CC=C(C=C1)C2CCNCC2.Cl.Cl

Descripción

Application

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable