M9140

Methylene blue

Dye content, ≥82%, certified by the Biological Stain Commission, powder

• Synonyme(s) : Basic Blue 9, 3,7-bis(Dimethylamino)phenazathionium chloride, Tetramethylthionine chloride
• Formule empirique (notation de Hill): C₁₆H₁₈ClN₃S · xH₂O
• Numéro CAS: 122965-43-9
• Poids moléculaire : 319.85 (anhydrous basis)
• Numéro C.I. (Colour Index): 52015
• Numéro Beilstein : 3599847
• Numéro CE : 200-515-2
• Numéro MDL: MFCD00150006
• Code UNSPSC : 12171500
• ID de substance PubChem : 24897317
• Nomenclature NACRES : NA.47

Propriétés

• product name: Methylene blue, certified by the Biological Stain Commission
• Qualité: certified by the Biological Stain Commission
• Niveau de qualité: 200
• Forme: powder
• Composition: Dye content, ≥82%
• Couleur: dark green
• Solubilité: H₂O: 4mg/4ml
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: CN(C)C1=CC=C2C(SC(C3=N2)=CC(C=C3)=[N+](C)C)=C1.[H]O[H].[Cl-]
• InChI: 1S/C16H18N3S.ClH.H2O/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10H,1-4H3;1H;1H2/q+1;;/p-1
• Clé InChI: WQVSELLRAGBDLX-UHFFFAOYSA-M
• Informations sur le gène: human ... CYP1A2(1544) , GSR(2936)

Description

Description générale

Methylene blue is a compound that occurs as crystals or crystalline powder, having a bronze-like luster. It is soluble in water, chloroform and partially soluble in alcohol. It is a photoactive dye, which is a member of phenothiazine family.

Application

Methylene blue has been used:

• to stain vaginal cells
• for the preparation of protein aqueous ink
• to evaluate cell survival by staining

Actions biochimiques/physiologiques

Methylene blue is used as a bacteriologic stain or dye and indicator. It mediates the inactivation of enveloped viruses in plasma, when exposed to visible light. It is an inhibitor of nitric oxide synthase and guanylate cyclase. It also plays a key role in medicine as an antimalarial agent, reducing agent in methemoglobinemia and inducer of apoptosis in cancer cells.

Adéquation

Certified for use in Mallory′s phloxine-methylene blue stain; Levine & Black stain for bacteria in milk; Wright stain for blood smears.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves