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SML0998

Sigma-Aldrich

AdipoRon

≥98% (HPLC)

Synonym(e):

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide, AdipoR agonist

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5 MG
123,00 €
25 MG
469,00 €

123,00 €

Versandbereit am14. April 2025Details

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5 MG
123,00 €
25 MG
469,00 €

About This Item

Empirische Formel (Hill-System):
C27H28N2O3
CAS-Nummer:
924416-43-3
Molekulargewicht:
428.52
UNSPSC-Code:
51111800
NACRES:
NA.77

123,00 €

Versandbereit am14. April 2025Details

Bulk-Bestellung anfordern

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 10 mg/mL, clear

Lagertemp.

room temp

SMILES String

N2(CCC(CC2)NC(=O)COc3ccc(cc3)C(=O)c4ccccc4)Cc1ccccc1

InChI

1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)

InChIKey

SHHUPGSHGSNPDB-UHFFFAOYSA-N

Biochem./physiol. Wirkung

AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.
AdipoRon is an adiponectin agonist.
Oral administration of adipoRon reduced postischemic oxidative stress showing lower expression of NADPH (Nicotinamide adenine diphosphate) oxidase and superoxide production in mouse model. Hence, adipoRon might be considered as a cardioprotective molecule.[1]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000408834
0000408838
0000382585
0000408838
0000408834

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Die Dokumentenbibliothek aufrufen

AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.
Zhang Y, et al.
American Journal of Physiology. Endocrinology and Metabolism, 309(3), E275-E282 (2015)
Sonja Lindfors et al.
Diabetologia, 64(8), 1866-1879 (2021-05-15)
Chronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related renal injury. Reduced serum concentration of anti-inflammatory adiponectin may promote chronic inflammation. Here, we investigated the potential anti-inflammatory and renoprotective effects and mechanisms
Maria-Bernadette Madel et al.
Frontiers in cell and developmental biology, 9, 627153-627153 (2021-04-20)
Long bones from mammals host blood cell formation and contain multiple cell types, including adipocytes. Physiological functions of bone marrow adipocytes are poorly documented. Herein, we used adipocyte-deficient PPARγ-whole body null mice to investigate the consequence of total adipocyte deficiency
Joshua A McDowell et al.
Redox biology, 73, 103219-103219 (2024-06-09)
Radiation causes damage to normal tissues that leads to increased oxidative stress, inflammation, and fibrosis, highlighting the need for the selective radioprotection of healthy tissues without hindering radiotherapy effectiveness in cancer. This study shows that adiponectin, an adipokine secreted by
Sanober Kafeel et al.
Cancers, 16(15) (2024-08-10)
Despite the countless therapeutic advances achieved over the years, non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. To this primacy contribute both non-oncogene addicted and advanced NSCLCs, in which conventional therapies are only partially effective. The
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