This product is a mixture of Oleic acid and Cyclodextrin. Each gram of powder will include a minimum of 28 mg Oleic acid. The product is sold by Oleic acid content. At the minimum Oleic acid content, the 10 mg package size would contain a total of 357 mg of powder. The Oleic acid content is lot specific. Please see the link below to review a sample or lot specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/o1257#product-documentation
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O1257
Oleic Acid-Water Soluble
powder, BioReagent, suitable for cell culture
Synonym(e):
Oleic Acid–Cyclodextrin Complex
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10 MG
92,20 €
About This Item
Empfohlene Produkte
Biologische Quelle
synthetic (organic)
Qualitätsniveau
Produktlinie
BioReagent
Form
powder
Zusammensetzung
Oleic acid, ~30 mg/g (balance methyl-β-cyclodextrin)
Methode(n)
cell culture | mammalian: suitable
Löslichkeit
H2O: 50 mg/mL, clear to slightly hazy
Lagertemp.
−20°C
SMILES String
CCCCCCCC\C=C/CCCCCCCC(O)=O
InChI
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChIKey
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
Angaben zum Gen
human ... SOAT1(6646) , SOAT2(8435)
Anwendung
Oleic Acid-Water Soluble has been used:
- to prepare the FFAs (free fatty acids) mixture for cell treatment[1]
- to investigate its effect on the solute carrier family 2 member 4 (SLC2A4)/GLUT4 expression in L6 muscle cells and as potential transcriptional regulators[2]
- in the preparation of fatting media for the induction of in vitro steatosis in primary human hepatocytes[3]
Sonstige Hinweise
Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media.
Ähnliches Produkt
Produkt-Nr.
Beschreibung
Preisangaben
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Lot/Batch Number
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Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells
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A20 attenuates FFAs-induced lipid accumulation in nonalcoholic steatohepatitis
Ai L, et al.
International Journal of Biological Sciences, 11(12), 1436-1436 (2015)
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International journal of biological sciences, 17(15), 4165-4175 (2021-11-23)
Background: Inflammation and apoptosis play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Suppressor of cytokine signaling 2 (SOCS2) is one of classic negative regulators of cytokine signaling, which has recently been described as anti-inflammatory mediators. However, the
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The phosphatidylinositol 3-kinase (PI3K) is frequently hyperactivated in cancer and plays important roles in both malignant and immune cells. The effect of PI3Kα inhibitors on the tumor microenvironment (TME) remains largely unknown. Here, we investigated the modulation of the TME
An effective protocol for pharmacological defatting of primary human hepatocytes which is non-toxic to cholangiocytes or intrahepatic endothelial cells
Boteon YL, et al.
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Artikel
Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
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Could you please clarify whether the entire 10mg of the compound is oleic acid, or does the 10mg compound actually contain 377ug (37.7mg/g * 10mg) of oleic acid, considering the specified concentration?
1 Antwort-
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