SML3216

Melarsoprol

≥98% (HPLC)

• Synonyma: (2-(4-(4,6-diamino-1,3,5-triazin-2-ylamino)phenyl)-1,3,2-dithiarsolan-4-yl)methanol, 2-(4-melamin-2-ylphenyl)-4-hydroxymethyl-1,3-dithia-2-arsolane, 2-p-(4,6-diamino-s-triazin-2-ylamino)phenyl-4-hydroxymethyl-1,3,2-dithiarsoline, Mel B, Melarsaprol, Melarsen B, RP 3854, p-[(4,6-diamino-s-triazin-2-yl)amino]dithiobenzenearsonous acid 3-hydroxypropylene ester
• Empirický vzorec (Hillův zápis): C₁₂H₁₅AsN₆OS₂
• Číslo CAS: 494-79-1
• Molekulová hmotnost: 398.34
• MDL number: MFCD00866803
• UNSPSC Code: 12352107
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=NC(N)=NC(NC2=CC=C(C=C2)[As]3SCC(S3)CO)=N1
• InChI: 1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)
• InChI key: JCYZMTMYPZHVBF-UHFFFAOYSA-N

Popis

Biochem/physiol Actions

Melarsoprol is an antiprotozoal (Trypanosoma) drug used in treatment of trypanosomiasis (Chagas disease and West African sleeping sickness). The drug mechanism of action is not well characterized. Melarsoprol is still the only effective drug for chemotherapy of second stage of T. b. rhodesiense sleeping sickness. As other arsenic-containing compounds melarsoprol causes cell apoptosis of myeloma and other cancer cell lines.

Bezpečnostní informace

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H331,H410
• pcodes: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable