SML2525

Tafluprost

≥98% (HPLC)

• Synonyma: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168
• Empirický vzorec (Hillův zápis): C₂₅H₃₄F₂O₅
• Číslo CAS: 209860-87-7
• Molekulová hmotnost: 452.53
• MDL number: MFCD08062150
• UNSPSC Code: 51111800
• NACRES: NA.77

Vlastnosti

• assay: ≥98% (HPLC)
• form: oil
• optical activity: [α]/D +20 to +25°, c = 1 in chloroform-d
• color: colorless to yellow
• storage temp.: −20°C
• InChI: 1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+
• InChI key: WSNODXPBBALQOF-ZHDUIJGQSA-N

Popis

Biochem/physiol Actions

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable