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Hlavní dokumenty

SML0860

Sigma-Aldrich

Arbidol hydrochloride

≥98% (HPLC)

Synonyma:

6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-Indole-3-carboxylic acid ethyl ester monohydrochloride

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About This Item

Empirický vzorec (Hillův zápis):
C22H25BrN2O3S · HCl
Číslo CAS:
131707-23-8
Molekulová hmotnost:
513.88
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

S(Cc2[n](c3c(c(c(c(c3)Br)O)CN(C)C)c2C(=O)OCC)C)c1ccccc1.[Cl-].O.[H+]

InChI

1S/C22H25BrN2O3S.ClH.H2O/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;;/h6-11,26H,5,12-13H2,1-4H3;1H;1H2

InChI key

PLWQHPWNKPKQJT-UHFFFAOYSA-N

Biochem/physiol Actions

Arbidol hydrochloride (ARB) is a small monocular compound. It is used to prevent severe pneumonia and virus-associated cytokine dysregulation induced by influenza viruses (IFV). ARB also possesses some immunomodulatory properties, including the effects of interferon induction and macrophage activation.
Arbidol is a broad-spectrum antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses, and is used clinically to treat influenza. Arbidol inhibits viral entry into host cell and stimulates immune response. Arbidol inhibits fusion between the viral capsid and the cell membrane of the target cell, thus preventing viral entry.
Arbidol is an anti-influenza antiviral agent.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Osvědčení o analýze (COA)

Lot/Batch Number
0000127362
0000127363
0000125115
0000122398
0000122397

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Ilenia Delogu et al.
Antiviral research, 90(3), 99-107 (2011-03-29)
Arbidol (ARB) is an antiviral drug originally licensed in Russia for use against influenza and other respiratory viral infections. Although a broad-spectrum antiviral activity has been reported for this drug, there is until now no data regarding its effects against
A A Romanovskaia et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 54(5-6), 41-47 (2010-01-08)
Biological properties of influenza viruses A (H1N1), that were the cause of the infection in humans in April - May 2009, and the action of the Russian antivirals on their reproduction were studied in vitro. The nucleotide sequence in the
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.
Liu Q, et al.
Acta Pharmacologica Sinica, 34(8), 1075-1075 (2013)
Yaxin Sun et al.
International journal of clinical pharmacology and therapeutics, 51(5), 423-432 (2013-02-09)
Arbidol is licensed in Russia and China for prophylaxis and treatment of influenza A and B. This study was to assess the pharmacokinetics of single and multiple doses of arbidol in healthy Chinese volunteers. This was a single-center, open-label, two-phase
S Ia Loginova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 55(7-8), 10-12 (2010-12-15)
The experimental study of the Ingavirin efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue and Arbidol showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protectiom of the
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