R9644

Ribavirin

≥98% (TLC), IMP dehydrogenase inhibitor, powder

• Synonyma: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
• Empirický vzorec (Hillův zápis): C₈H₁₂N₄O₅
• Číslo CAS: 36791-04-5
• Molekulová hmotnost: 244.20
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278685
• NACRES: NA.77
• MDL number: MFCD00058564

Vlastnosti

• Název produktu: Ribavirin, antiviral
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
• antibiotic activity spectrum: viruses
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
• InChI key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• Gene Information: human ... IMPDH1(3614), IMPDH2(3615)

Popis

General description

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Chemical structure: nucleoside

Biochem/physiol Actions

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.

Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Danger
• hcodes: H341,H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges