S3147

5-Sulfosalicylic acid dihydrate

suitable for electrophoresis, ≥99%

• Synonyma: 2-Hydroxy-5-sulfobenzoic acid
• Lineární vzorec: HO₃SC₆H₃-2-(OH)CO₂H·2H₂O
• Číslo CAS: 5965-83-3
• Molekulová hmotnost: 254.21
• Beilstein/REAXYS Number: 650741
• EC Number: 202-555-6
• MDL number: MFCD00149540
• UNSPSC Code: 41105319
• PubChem Substance ID: 24899547
• NACRES: NB.22

Vlastnosti

• Quality Level: 200
• assay: ≥99%
• form: powder or crystals
• technique(s): electrophoresis: suitable
• impurities: ≤0.02% Insoluble matter; ≤0.05% Salicylic Acid
• mp: 105-110 °C (lit.)
• solubility: water: soluble 100 mg/mL, clear, colorless
• anion traces: chloride (Cl^-): ≤0.001%; sulfate (SO₄^2-): ≤0.035%
• cation traces: Fe: ≤0.001%; heavy metals (as Pb): ≤0.002%
• SMILES string: [H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O
• InChI: 1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2
• InChI key: BHDKTFQBRFWJKR-UHFFFAOYSA-N

Popis

General description

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Application

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.

5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

Analysis Note

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

Bezpečnostní informace

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves