T4885

Trichloroacetic acid

≥99.0% (titration)

• Synonyma: TCA
• Lineární vzorec: Cl₃CCOOH
• Číslo CAS: 76-03-9
• Molekulová hmotnost: 163.39
• Beilstein/REAXYS Number: 970119
• EC Number: 200-927-2
• MDL number: MFCD00004177
• UNSPSC Code: 12352100
• PubChem Substance ID: 24900233
• NACRES: NA.21

Vlastnosti

• vapor density: <1 (vs air)
• Quality Level: 200
• vapor pressure: 1 mmHg ( 51 °C)
• assay: ≥99.0% (titration)
• form: powder or crystals
• refractive index: n20/D 1.62 (lit.)
• pH: 1 (at 25 °C, 81,7 g/L)
• bp: 196 °C (lit.)
• mp: 54-58 °C (lit.)
• solubility: H₂O: 1 g/10 mL
• density: 1.62 g/mL at 25 °C (lit.)
• functional group: carboxylic acid; chloro
• storage temp.: 2-8°C
• SMILES string: OC(=O)C(Cl)(Cl)Cl
• InChI: 1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: YNJBWRMUSHSURL-UHFFFAOYSA-N

Popis

Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Trichloroacetic acid (TCA) can be used as a catalyst to synthesize:

• β-enaminones via condensation reaction of 1,3-dicarbonyl compounds and amines.
• 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives via four-component condensation reaction of ethyl acetoacetate, phenylhydrazine, malononitrile, and aromatic aldehydes.
• Tetrahydrobenzo[a]xanthen-11-ones by three-component reaction of aldehydes, 2-naphthol and dimedone.

Bezpečnostní informace

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H314,H410
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class: 8B - Non-combustible corrosive hazardous materials
• wgk_germany: WGK 2
• flash_point_f: >235.4 °F - closed cup
• flash_point_c: > 113 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges