E1905

(+)-Etomoxir sodium salt hydrate

≥98% (HPLC), powder, CPT-1 inhibitor

• Synonyma: R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
• Empirický vzorec (Hillův zápis): C₁₅H₁₈ClO₄ · Na · H₂O
• Číslo CAS: 828934-41-4
• Molekulová hmotnost: 338.76
• MDL number: MFCD11044452
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724474
• NACRES: NA.77

Vlastnosti

• product name: (+)-Etomoxir sodium salt hydrate, ≥98% (HPLC), powder
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: H₂O: freely soluble
• storage temp.: 2-8°C
• SMILES string: O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
• InChI: 1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
• Inchi Key: WENJLJJSJDAJDN-QCUBGVIVSA-M

Popis

General description

(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors. It favors oxidative stress in T cells and prevents T cell differentiation. It inhibits fatty acid oxidation and promotes hunger and food intake. Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.

Application

(+)-Etomoxir sodium salt hydrate has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.

Biochem/physiol Actions

Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator

Packaging

Store tightly sealed, protected from exposure to light

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves