D4321

Dihydroeponemycin

≥98% (HPLC)

• Empirický vzorec (Hillův zápis): C₂₀H₃₆N₂O₆
• Číslo CAS: 126463-64-7
• Molekulová hmotnost: 400.51
• MDL number: MFCD17215971
• UNSPSC Code: 12352202
• PubChem Substance ID: 329798798
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D ±35.7°
• color: off-white to light tan
• solubility: DMSO: ≥1 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)CCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO)CO1
• InChI: 1S/C20H36N2O6/c1-13(2)7-5-6-8-17(25)21-16(10-23)19(27)22-15(9-14(3)4)18(26)20(11-24)12-28-20/h13-16,23-24H,5-12H2,1-4H3,(H,21,25)(H,22,27)/t15-,16-,20+/m0/s1
• InChI key: IUDBVFIQSSOIDB-TWOQFEAHSA-N

Popis

Biochem/physiol Actions

Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus.

Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable