1338313

Imiquimod

United States Pharmacopeia (USP) Reference Standard

• Synonyma: Imiquimod, 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine
• Empirický vzorec (Hillův zápis): C₁₄H₁₆N₄
• Číslo CAS: 99011-02-6
• Molekulová hmotnost: 240.30
• NACRES: NA.24
• PubChem Substance ID: 329750158
• UNSPSC Code: 41116107
• MDL number: MFCD00866946

Vlastnosti

• Název produktu: Imiquimod, United States Pharmacopeia (USP) Reference Standard
• InChI: 1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
• SMILES string: CC(C)Cn1cnc2c(N)nc3ccccc3c12
• InChI key: DOUYETYNHWVLEO-UHFFFAOYSA-N
• grade: pharmaceutical primary standard
• API family: imiquimod
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• Gene Information: human ... TLR7(51284)

Popis

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Imiquimod USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Imiquimod Cream

Biochem/physiol Actions

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo and acts as an immunomodulator with anti-viral and anti-inflammatory perties.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319
• pcodes: P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable