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C6473

Sigma-Aldrich

Monoclonal Anti-CXCR3 antibody produced in mouse

clone 49801.111, purified immunoglobulin, lyophilized powder

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About This Item

MDL number:
MFCD01864634
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

49801.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1

UniProt accession no.

P49682

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CXCR3(2833)
mouse ... Cxcr3(12766)

Související kategorie

General description

Chemokine receptor CXCR3 also refers as IP -10 or Mig receptor is a Gαi protein-coupled receptor and is highly expressed by IL-2-activated T lymphocytes (Th1). It facilitates calcium mobilization and chemotaxis. It also plays a pivotal role in wound healing. Monoclonal Anti-CXCR3 antibody can be used in flow cytometry for the Identification of CXCR-3. Mouse anti-CXCR3 antibody reacts specifically with CXCR-3 transfected cells but not with the parent cell line. The product has shown no cross-reactivity with human CXCR-1, CXCR-2 and CXCR-4.

Specificity

The antibody reacts with human CXCR3 transfectant cells and not the parent cell line. It has no cross-reactivity with CXCR1, CXCR2, or CXCR4.

Immunogen

human CXCR3 transfected NSO mouse myeloma cells.

Application

Monoclonal Anti-CXCR3 antibody can be used as a positive control in immunohistochemical staining.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

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Journal of leukocyte biology, 83(4), 875-882 (2008-01-05)
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Replacement of wounded skin requires the initially florid cellular response to abate and even regress as the dermal layer returns to a relatively paucicellular state. The signals that direct this "stop and return" process have yet to be deciphered. CXCR3

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