90834

Bradykinin acetate salt

analytical standard

• Empirický vzorec (Hillův zápis): C₅₀H₇₃N₁₅O₁₁ · xC₂H₄O₂
• Číslo CAS: 6846-03-3
• Molekulová hmotnost: 1060.21 (free base basis)
• EC Number: 227-781-2
• MDL number: MFCD00076258
• UNSPSC Code: 85151701
• NACRES: NA.24

Vlastnosti

• grade: analytical standard
• Quality Level: 100
• assay: ≥98.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• analyte chemical class(es): peptides
• technique(s): HPLC: suitable
• impurities: ≤10 wt. % water
• color: white
• application(s): food and beverages
• format: neat
• storage temp.: 2-8°C
• SMILES string: N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
• InChI key: QXZGBUJJYSLZLT-FDISYFBBSA-N

Popis

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Application

Bradykinin acetate salt may be used as a precursor for the preparation of bradykinin (BK) prior to its determination from acidic aqueous solutions by electromembrane extraction (EME) followed by analysis using high performance liquid chromatography (HPLC) with ultraviolet (UV) detector.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Activates pain receptors; induces smooth muscle contraction; activates Ca²⁺-dependent nitric oxide synthetase; increases capillary permeability.

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable