26454

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

• Synonyma: Stearic acid magnesium salt
• Lineární vzorec: [CH₃(CH₂)₁₆CO₂]₂Mg
• Číslo CAS: 557-04-0
• Molekulová hmotnost: 591.24
• Beilstein/REAXYS Number: 3919702
• EC Number: 209-150-3
• MDL number: MFCD00036391
• UNSPSC Code: 12352106
• PubChem Substance ID: 57648176
• NACRES: NA.22

Vlastnosti

• grade: puriss.
• assay: ≥40% stearic acid basis (GC); ≥90% stearic and palmitic acid basis; 4.0-5.0% Mg basis (calc on dry sub.)
• quality: meets analytical specification of Ph. Eur., BP
• impurities: acidity or alkalinity, complies; microbiological impurity, in accordance; residual solvents, complies
• loss: ≤6.0% loss on drying, 105 °C
• mp: 200 °C (lit.)
• acid value: 195‑210(fatty acid)
• solubility: alcohol: insoluble; diethyl ether: insoluble; water: insoluble
• anion traces: chloride (Cl^-): ≤1000 mg/kg; sulfate (SO₄^2-): ≤5000 mg/kg
• cation traces: Cd: ≤3 mg/kg; Ni: ≤5 mg/kg; Pb: ≤10 mg/kg
• suitability: in accordance for fatty acid composition; passes test for identity
• application(s): pharmaceutical (small molecule)
• SMILES string: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
• InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
• InChI key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Popis

Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves