8.52040

Fmoc-Lys(Tfa)-OH

Novabiochem^®

• Synonyma: Fmoc-Lys(Tfa)-OH, N-α-Fmoc-N-ε-trifluoroacetyl-L-lysine
• Empirický vzorec (Hillův zápis): C₂₃H₂₃F₃N₂O₅
• Číslo CAS: 76265-69-5
• Molekulová hmotnost: 464.43
• MDL number: MFCD00153360
• UNSPSC Code: 12352209
• NACRES: NA.22

Vlastnosti

• Quality Level: 200
• product line: Novabiochem^®
• assay: ≥97% (TLC); ≥97.0% (HPLC); ≥97.0% (acidimetric)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 150-160 °C
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 2-30°C
• SMILES string: FC(F)(F)C(=O)NCCCC[C@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)C(=O)O
• InChI: 1S/C23H23F3N2O5/c24-23(25,26)21(31)27-12-6-5-11-19(20(29)30)28-22(32)33-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18-19H,5-6,11-13H2,(H,27,31)(H,28,32)(H,29,30)/t19-/m0/s1
• InChI key: ZVLMWTPNDXNXSZ-IBGZPJMESA-N

Popis

General description

Building block for introduction of lysine amino-acid residues bearing orthogonal side-chain protection. The trifluoroacetyl group can be selectively removed by aqueous basic hydrolysis ^[1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] E. Atherton, et al. (1980) J. Chem. Soc., Chem. Commun., 970.
^[2] D. A. Stetsenko & M. J. Gait (2001) Bioconjugate Chem., 12, 576.

Linkage

Replaces: 04-12-1083

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Purity (TLC(0811)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable