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220957

Sigma-Aldrich

Tilorone dihydrochloride

95%

Synonyma:

2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

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About This Item

Empirický vzorec (Hillův zápis):
C25H34N2O3 · 2HCl
Číslo CAS:
27591-69-1
Molekulová hmotnost:
483.47
MDL number:
MFCD00134071
UNSPSC Code:
12352100
PubChem Substance ID:
24853201
NACRES:
NA.22

assay

95%

mp

230-233 °C (lit.)

SMILES string

Cl[H].Cl[H].CCN(CC)CCOc1ccc2-c3ccc(OCCN(CC)CC)cc3C(=O)c2c1

InChI

1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H

InChI key

BSVYJQAWONIOOU-UHFFFAOYSA-N

General description

Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.

Application

Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).

Pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Osvědčení o analýze (COA)

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Sigma-Aldrich

C6628

Chloroquine diphosphate salt

Xianhua Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 492-496 (2010-01-02)
A highly sensitive and selective HPLC-MS/MS method is presented for the quantitative determination of tiloronoxim and its metabolite tilorone in human blood. An aliquot of 200 microl human blood was extracted with a mixture of chloroform/ethyl ether (1/2, v/v), using
O I Skrots'ka et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 69(3), 62-68 (2007-08-09)
The authors studied the antiviral effect of an interferonogenic yeast RNA-tilorone molecular complex (MC) compared to the Virolex, videly used antiherpetic drug, and standard interferon (IFN) alpha/beta inducer poly(I)poly(C) in Vero cells culture infected with herpes simplex type I virus
H M Burke et al.
Journal of medicinal chemistry, 21(10), 1084-1086 (1978-10-01)
New synthetic routes to the orally active, interferon-inducing antiviral agent tilorone dihydrochloride, 2,7-bis-[(diethylamino)ethoxy]fluoren-9-one dihydrochloride (1a), were developed. The routes involved the preparation and solvolysis of tetrazonium fluoroborate salts of 2,7-diaminofluoren-9-one. Nonplanar (1b), 9-sulfone (1c), and fluorene (1d) analogues of tilorone
Vladimir G Zinkovsky et al.
Pharmacological reports : PR, 59(6), 739-751 (2008-01-16)
Pharmacokinetics of amixin, a synthetic interferon inducer, has been studied in mice under intravenous and oral routes of administration. Following oral administration, 80% of the drug was eliminated in the unchanged form. Its absolute biological availability comprised 0.7. In comparison
N Ya Golovenko et al.
Bulletin of experimental biology and medicine, 140(6), 708-710 (2006-07-20)
Pharmacokinetics of amixin was studied after repeated administration (5 days) to animals. Perorally administered amixin is characterized by high bioavailability and is present in the circulation in high concentrations for a long time. The main pharmacokinetic parameters were estimated by
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