174823
4-Quinolinecarboxylic acid
97%
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
Empirický vzorec (Hillův zápis):
C10H7NO2
Číslo CAS:
Molekulová hmotnost:
173.17
Beilstein/REAXYS Number:
5224
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Doporučené produkty
assay
97%
mp
254-255 °C (lit.)
functional group
carboxylic acid
SMILES string
OC(=O)c1ccnc2ccccc12
InChI
1S/C10H7NO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H,12,13)
InChI key
VQMSRUREDGBWKT-UHFFFAOYSA-N
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Application
4-Quinolinecarboxylic acid was used in the coupling reaction with diamine linker. A 4-quinolinecarboxylic acid analogue, brequinar sodium was used to inhibit dihydroorotate dehydrogenase and the de novo biosynthesis of pyrimidine.
Biochem/physiol Actions
4-Quinolinecarboxylic acid showed anti-tumor activity against L1210 leukemia and B16 melanoma.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.
Solid-phase synthesis of substituted quinoline and isoquinoline derivatives using heterocyclic N-oxide chemistry.
Tetrahedron Letters, 39(27), 4749-4752 (1998)
He Huang et al.
The Journal of organic chemistry, 74(15), 5476-5480 (2009-07-04)
We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried
D L Dexter et al.
Cancer research, 45(11 Pt 1), 5563-5568 (1985-11-01)
A novel, substituted 4-quinolinecarboxylic acid (NSC 339768) demonstrated antitumor activity against L1210 leukemia and B16 melanoma in the National Cancer Institute's Developmental Therapeutics Program. An extensive analogue synthesis program was initiated; over 200 derivatives were synthesized and tested for anticancer
Dorothée Duvelleroy et al.
Organic & biomolecular chemistry, 3(20), 3794-3804 (2005-10-08)
Rapid synthesis of quinoline-4-carboxylic acid derivatives has been achieved by reaction of 2-methoxy acrylates or acrylamides with N-arylbenzaldimines in acetonitrile under InCl3 catalysis and microwave irradiation. Isolated yields up to 57% within 3 min have been obtained. The Lewis acid
7-Methyl-thiocinchoninamide.
A G RENFREW
Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 40(9), 467-467 (1951-09-01)
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