T144

(±)-Thalidomide

≥98%, powder

• Sinónimos: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Fórmula empírica (notación de Hill): C₁₃H₁₀N₂O₄
• Número de CAS: 50-35-1
• Peso molecular: 258.23
• Número CE: 200-031-1
• Número MDL: MFCD00153873
• Código UNSPSC: 12352111
• eCl@ss: 39180303
• ID de la sustancia en PubChem: 24278765
• NACRES: NA.77

Propiedades

• ligand: thalidomide
• Ensayo: ≥98%
• Formulario: powder
• idoneidad de la reacción: reagent type: ligand
• color: white
• solubilidad: DMSO: 20 mg/mL, clear
• emisor: Celgene
• cadena SMILES: O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• Clave InChI: UEJJHQNACJXSKW-UHFFFAOYSA-N
• Información sobre el gen: human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , LITAF(9516) , RBX1(9978) , TNF(7124) ; mouse ... Nos2(18126) ; rat ... Nos1(24598)

Descripción

Aplicación

Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.

Acciones bioquímicas o fisiológicas

(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.

Características y beneficios

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparación

Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H312,H360D
• Consejos de prudencia: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Clasificaciones de peligro: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges