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C0737

Cilostazol

Name: Cilostazol
Brand: SIGMA
Price: 178000 CLP

≥98% (HPLC), Phosphodiesterase III (PDE3) inhibitor, powder

Sinónimos:

6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal

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A ustedes/SKU	Disponibilidad	Precio
10 mg	Comprobar disponibilidad del carrito	$178.000
50 mg	Comprobar disponibilidad del carrito	$703.000

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₂₀H₂₇N₅O₂

Número CAS:

73963-72-1

Peso molecular:

369.46

UNSPSC Code:

41106305

PubChem Substance ID:

24278291

NACRES:

NA.77

MDL number:

MFCD00866780

Assay:

≥98% (HPLC)

Form:

powder

$178.000

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Propiedades

Nombre del producto

Cilostazol, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: 10 mg/mL, clear

originator

Otsuka Pharma

SMILES string

O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1

InChI

1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

InChI key

RRGUKTPIGVIEKM-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139), PDE3B(5140)

Descripción

General description

Cilostazol prevents platelet aggregation and has vasodilatory properties. It is used to treat chronic arterial disease and intermittent claudication. Cilostazol has antiproliferative effects and improves the properties of prostacyclin. It regulates cell proliferation, stimulates cyclic adenosine monophosphate (cAMP) level and induces cyclic AMP-dependent protein kinase.

Application

Cilostazol has been used:

to reduce Madin–Darby cell line (MDCK) proliferation through c-Myc down-regulation
in the in vitro assessment of toxin delivery in T84 intestinal epithelial cells
to induce adenosine triphosphate (ATP) release in white adipocytes

Biochem/physiol Actions

Phosphodiesterase III (PDE3) inhibitor

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Otsuka Pharma. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Este artículo	1134153	SML1447	PHR1503
Sigma-Aldrich C0737 Cilostazol	USP 1134153 Cilostazol	Sigma-Aldrich SML1447 Clemizole hydrochloride	Supelco PHR1503 Cilostazol
description ≥98% (HPLC), powder	description United States Pharmacopeia (USP) Reference Standard	description ≥98% (HPLC)	description Pharmaceutical Secondary Standard; Certified Reference Material
form powder	form -	form powder	form -
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay -
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 300
solubility DMSO: 10 mg/mL, clear	solubility -	solubility H₂O: 2 mg/mL, clear (warmed)	solubility -
color off-white	color -	color white to beige	color -
originator Otsuka Pharma	originator -	originator -	originator -

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pictograms

GHS08

signalword

Warning

hcodes

H361d

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c