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P0018

Pomalidomide

Name: Pomalidomide
Brand: SIGMA
Price: 120000 CLP

≥98% (HPLC), powder, HbF inducer

Oferta disponible

Sinónimos:

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3

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Talla/SKU	Disponibilidad	Precio
5 mg	Comprobar disponibilidad del carrito	$120.000
25 mg	Comprobar disponibilidad del carrito	$484.000 $411.400

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₃H₁₁N₃O₄

Número CAS:

19171-19-8

Peso molecular:

273.24

UNSPSC Code:

12352200

PubChem Substance ID:

329819974

NACRES:

NA.77

MDL number:

MFCD12756407

Assay:

≥98% (HPLC)

Form:

powder

$120.000

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Propiedades

Nombre del producto

Pomalidomide, ≥98% (HPLC)

ligand

pomalidomide

Quality Segment

100

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: ligand

color

yellow

solubility

DMSO: ≥14 mg/mL

storage temp.

2-8°C

SMILES string

Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI

1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChI key

UVSMNLNDYGZFPF-UHFFFAOYSA-N

Gene Information

human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Descripción

Application

Pomalidomide has been used:

to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
for apoptosis studies and intracellular calcium analysis
as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Biochem/physiol Actions

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Este artículo	930563	SML2283	930571
Sigma-Aldrich P0018 Pomalidomide	Sigma-Aldrich 930563 Pomalidomide-PEG₂-C₂-azide	Sigma-Aldrich SML2283 Lenalidomide	Sigma-Aldrich 930571 Pomalidomide-piperidine-carboxylic acid
description ≥98% (HPLC)	description ≥95%	description ≥98% (HPLC)	description ≥95%
assay ≥98% (HPLC)	assay ≥95%	assay ≥98% (HPLC)	assay ≥95%
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥14 mg/mL	solubility -	solubility DMSO: 2 mg/mL, clear	solubility -
color yellow	color -	color white to beige	color -