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Merck
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SAB3500023

Sigma-Aldrich

Anti-TUBA1A (TUBA3) Antibody

chicken polyclonal

Sinónimos:

Anti-LIS3, Anti-TUBA1A, Anti-TUBA3, Anti-Tubulin alpha-1A

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About This Item

Número MDL:
MFCD00145891
Código UNSPSC:
12352203
NACRES:
NA.41

Nombre del producto

Anti-α-Tubulin from chicken, affinity isolated antibody, buffered aqueous solution

origen biológico

chicken

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

rat, human, mouse

técnicas

indirect ELISA: suitable
western blot: suitable

Nº de acceso NCBI

CAA25855

Nº de acceso UniProt

Q13748

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... TUBA1A(7846)

Descripción general

Tubulin α 1A (TUBA1A) is a member of α-tubulin gene family. It is encoded by the gene mapped to human chromosome 12q13.12. Tubulin α 1A is a vital structural subunit of microtubules that are temporarily expressed in almost all post-mitotic neurons during neuronal development. The encoded protein structure contains a core of two β-sheets enclosed by α-helices. TUBA1A is characterized with an amino-terminal domain having guanine nucleotide-binding region, an intermediate domain and a carboxy-terminal domain.

Inmunógeno

Tubulin antibody was raised against a 16 amino acid peptide near the amino terminus of human Tubulin.

Aplicación

Anti-α-tubulin from chicken has been used for Western blotting and immunohistochemistry.

Acciones bioquímicas o fisiológicas

Gene mutation of tubulin α-1A (TUBA1A) is observed in perisylvian asymmetrical polymicrogyria, polymicrogyria-like cortical dysplasia, and microlissencephaly in fetal cases. Alteration in the expression of the gene impairs neural migration and causes lissencephaly (LIS).

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligadura / enlace

The action of this antibody can be blocked using blocking peptide SBP3500023.

Forma física

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descripción
Precios

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
58951003
51030903

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Ulf Brockmeier
PLoS ONE (2011)
Expanding the spectrum of TUBA1A-related cortical dysgenesis to Polymicrogyria.
Poirier k, et.al
European Journal of Human Genetics, 21(4), 381-385 (2013)
TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins.
Kumar RA, et.al
Human Molecular Genetics, 19(14), 2817-2827 (2010)
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