C6880

D-Cycloserine

• Sinónimos: (R)-4-Amino-3-isoxazolidone, 4-Amino-3-isoxazolidinone
• Fórmula empírica (notación de Hill): C₃H₆N₂O₂
• Número de CAS: 68-41-7
• Peso molecular: 102.09
• Beilstein: 80798
• Número CE: 200-688-4
• Número MDL: MFCD00005353
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24892907
• NACRES: NA.32

Propiedades

• Formulario: powder
• mp: 147 °C (dec.) (lit.)
• espectro de actividad antibiótica: Gram-negative bacteria; mycobacteria
• Modo de acción: cell wall synthesis | interferes
• temp. de almacenamiento: −20°C
• cadena SMILES: N[C@@H]1CONC1=O
• InChI: 1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
• Clave InChI: DYDCUQKUCUHJBH-UWTATZPHSA-N
• Información sobre el gen: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907) ; mouse ... GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168) ; rat ... GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668)

Descripción

Descripción general

Chemical structure: amino acid derivatives

Aplicación

D-Cycloserine (DCS) has been used:

• to study its effect on partner preference in Prairie Voles[1]
• to study its effect on grooming behaviour of rats[2]
• to determine its minimum inhibitory concentration (MIC) on 48 multidrug resistant tuberculosis (MDR-TB) isolates using the broth microdilution method[3]
• to study its effect on mouse model of autism, using behavioural assays[4]

Acciones bioquímicas o fisiológicas

D-cycloserine (DCS) was initially known as a tuberculostatic agent. It acts as a glutamatergic partial N-methyl-D-aspartate (NMDA) agonist. It binds at the glycine-binding site of the NMDA receptor and enable the opening of the NMDA channel.[5] DCS has a an ability to improve various forms of learning and memory hence, this drug might be effective for improving social memory and cognition.[1] DCS can be used as a potential therapeutic for psychiatric disorders such as phobias, social anxiety, obsessive-compulsive disorder, and posttraumatic stress disorder.[6]

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic.
Partial agonist at the glycine modulatory site of NMDA glutamatergic receptors; antibiotic against Gram-negative bacteria.
Mode of Resistance: D-Ala transport interference.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)